2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138511
    NHS ester-PEG7-COOH
    NHS ester-PEG7-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NHS ester-PEG7-COOH
  • HY-133369
    DBCO-NHCO-PEG3-acid
    DBCO-NHCO-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG3-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG3-acid
  • HY-140427
    Boc-Aminooxy-PEG3-C2-NH2 1235514-18-7
    Boc-Aminooxy-PEG3-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG3-C2-NH2
  • HY-140019
    Azido-PEG3-amide-C3-triethoxysilane 2243566-43-8
    Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-amide-C3-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-amide-C3-triethoxysilane
  • HY-134679
    N-Boc-C1-PEG5-C3-NH2 956472-77-8
    N-Boc-C1-PEG5-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-C1-PEG5-C3-NH2
  • HY-140901
    Biotin-PEG23-amine
    Biotin-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG23-amine
  • HY-141280
    Methyltetrazine-PEG24-NH-Boc
    Methyltetrazine-PEG24-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG24-NH-Boc
  • HY-133373
    DBCO-NHCO-PEG6-maleimide
    DBCO-NHCO-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG6-maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG6-maleimide
  • HY-140778
    Azide-PEG5-Boc 1415800-41-7
    Azide-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG5-Boc
  • HY-140062
    Propargyl-PEG17-methane 2169967-47-7
    Propargyl-PEG17-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG17-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG17-methane
  • HY-W096150
    Dimethylamino-PEG3 2741-30-2
    Dimethylamino-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dimethylamino-PEG3
  • HY-141327
    Thiol-PEG3-Boc 1446282-39-8
    Thiol-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG3-Boc
  • HY-140260
    NH-bis(PEG3-C2-NH-Boc) 2055024-51-4
    NH-bis(PEG3-C2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG3-C2-NH-Boc)
  • HY-141401
    m-PEG13-Boc
    m-PEG13-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG13-Boc
  • HY-140186
    Amino-PEG36-acid 2241751-76-6
    Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG36-acid
  • HY-134693
    Azido-C1-PEG4-C3-NH2
    Azido-C1-PEG4-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-C1-PEG4-C3-NH2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-C1-PEG4-C3-NH2
  • HY-140622
    Ald-Ph-amido-PEG24-acid
    Ald-Ph-amido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ald-Ph-amido-PEG24-acid
  • HY-132107
    MS-PEG3-THP 357204-84-3
    MS-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    MS-PEG3-THP
  • HY-140562
    N-(Azido-PEG2)-N-Boc-PEG3-Boc 2093153-07-0
    N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Boc-PEG3-Boc
  • HY-140444
    Cbz-aminooxy-PEG8-Boc
    Cbz-aminooxy-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-aminooxy-PEG8-Boc
PROTAC Linkers Isoform Comparison

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